Calbistrins, novel antifungal agents produced by Penicillium restrictum. II. Isolation and elucidation of structure.

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Calbistrins, novel antifungal agents produced by Penicillium restrictum. I. Production, taxonomy of the producing organism and biological activity.

A novel antibiotic complex, named the calbistrins, has been discovered in the culture broth of a soil fungus. The producing organism, designated AB 1875C-28, was identified as a strain of Penicillium restrictum. Calbistrin A, the most potent of the 4-membered complex, has MICs of 0.78 micrograms/ml against Candida albicans. Only poor activity is observed against non-candida yeasts, filamentous ...

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ژورنال

عنوان ژورنال: The Journal of Antibiotics

سال: 1993

ISSN: 0021-8820,1881-1469

DOI: 10.7164/antibiotics.46.39